Ideally, the levels of protein in urine are nearly negligible. This condition can be an indication of a kidney disease. The term ‘hypoglobulinemia’ refers to low levels of globulin in the blood. Given below are details regarding when low levels of globulin are seen and what it signifies. It is observed that a low A/G ratio may result in excessive production of globulins in diseases like multiple myeloma, or inadequate production of globulins in diseases like cirrhosis. This test is important as it helps in diagnosing various disorders like liver diseases, kidney disease (proteinuria), cirrhosis, autoimmune diseases, leukemias, and hormone imbalances as these are illnesses where the albumin levels drop considerably. The solubility and the electrophoretic migration rates of globulin are lower than those for albumin. Ideally, the ratio of albumin to globulin is 1.0 or more. Along with the individual levels of globulin, what is commonly calculated is the albumin/globulin ratio. The optimal range of globulin in the body is 2.3 to 2.8 g/dl. Since the gamma fraction usually makes up the largest portion of the globulins, antibody deficiency should always come to mind when there are low globulin levels in the blood. Globulin that forms a part of the immune system is the most important one, and is commonly referred to as immunoglobulin. Some globulins are produced in the liver, while others are secreted by the immune system. There are four major groups of globulins, which are alpha-1 globulins, alpha-2 globulins, beta globulins and gamma globulins. The specific profile of globulins is determined by protein electrophoresis which separates the proteins according to their size and charge. Globulins include gamma globulins (antibodies) and a variety of enzymes and protein molecules that act as carriers. Globulin is one of the serum proteins, the other one being albumin.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |